Abstract
Three new pimaren diterpenoids, ent-8(14)-pimarene-15R, 16-diol (1), ent-8(14)-pimarene-1alpha,15R,16-triol (2), and (5R, 9S, 10R, 13S, 15S)-ent-8(14)-pimarene-1-oxo-15R,16-diol (3), along with three known diterpenoids (4-6) have been isolated from the stem of mangrove plant Bruguiera gymnorrhiza. The structures of compounds 1-3 were determined by extensive spectroscopic (2D NMR, MS, IR, and CD) analysis, and 3 and 5 showed moderate cytotoxic activities against L-929 and K562, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes / chemistry*
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Abietanes / isolation & purification
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Cell Line, Tumor
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Circular Dichroism
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Drug Screening Assays, Antitumor
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Humans
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Indicators and Reagents
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K562 Cells
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Plant Stems / chemistry
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Rhizophoraceae / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
Substances
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(5R, 9S, 10R, 13S, 15S)-ent-8(14)-pimarene-1-oxo-15R,16-diol
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Abietanes
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Indicators and Reagents
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ent-8(14)-pimarene-15R, 16-diol
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ent-8(14)-pimarene-1alpha,15R,16-triol