Three new pimaren diterpenoids from marine mangrove plant, Bruguiera gymnorrhiza

Pharmazie. 2005 Sep;60(9):705-7.

Abstract

Three new pimaren diterpenoids, ent-8(14)-pimarene-15R, 16-diol (1), ent-8(14)-pimarene-1alpha,15R,16-triol (2), and (5R, 9S, 10R, 13S, 15S)-ent-8(14)-pimarene-1-oxo-15R,16-diol (3), along with three known diterpenoids (4-6) have been isolated from the stem of mangrove plant Bruguiera gymnorrhiza. The structures of compounds 1-3 were determined by extensive spectroscopic (2D NMR, MS, IR, and CD) analysis, and 3 and 5 showed moderate cytotoxic activities against L-929 and K562, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemistry*
  • Abietanes / isolation & purification
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Cell Line, Tumor
  • Circular Dichroism
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Drug Screening Assays, Antitumor
  • Humans
  • Indicators and Reagents
  • K562 Cells
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Plant Stems / chemistry
  • Rhizophoraceae / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared

Substances

  • (5R, 9S, 10R, 13S, 15S)-ent-8(14)-pimarene-1-oxo-15R,16-diol
  • Abietanes
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Indicators and Reagents
  • ent-8(14)-pimarene-15R, 16-diol
  • ent-8(14)-pimarene-1alpha,15R,16-triol