Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 310 (5748), 670-4

Small-molecule Inhibitor of Vibrio Cholerae Virulence and Intestinal Colonization

Affiliations

Small-molecule Inhibitor of Vibrio Cholerae Virulence and Intestinal Colonization

Deborah T Hung et al. Science.

Abstract

Increasing antibiotic resistance requires the development of new approaches to combating infection. Virulence gene expression in vivo represents a target for antibiotic discovery that has not yet been explored. A high-throughput, phenotypic screen was used to identify a small molecule 4-[N-(1,8-naphthalimide)]-n-butyric acid, virstatin, that inhibits virulence regulation in Vibrio cholerae. By inhibiting the transcriptional regulator ToxT, virstatin prevents expression of two critical V. cholerae virulence factors, cholera toxin and the toxin coregulated pilus. Orogastric administration of virstatin protects infant mice from intestinal colonization by V. cholerae.

Similar articles

See all similar articles

Cited by 137 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback