Long-term efficacy and tolerability of lanthanum carbonate: results from a 3-year study

Nephron Clin Pract. 2006;102(2):c61-71. doi: 10.1159/000088932. Epub 2005 Oct 14.


Background: Control of serum phosphate over the long term is essential in patients with end-stage renal disease. Six-month and 2-year extensions to a 6-month study evaluated the long-term safety, tolerability and efficacy of the new phosphate binder lanthanum carbonate.

Methods: Patients who participated in a 6-month, randomized trial comparing lanthanum carbonate with calcium carbonate were eligible for a 24-week, open-label extension. Lanthanum carbonate-treated patients continued taking their established maintenance dose ('continued-lanthanum group') and calcium carbonate-treated patients switched to lanthanum carbonate, 375-3,000 mg/day ('switch group'). Patients could also enter a further 2-year extension. Efficacy parameters, including serum phosphate, were monitored.

Results: Mean serum phosphate was approximately 1.80 mmol/l throughout the trial. The percentage of patients with controlled serum phosphate (< or =1.80 mmol/l) after the 6-month extension was 63.3 and 58.4% in the continued-lanthanum and switch groups, respectively; after the 2-year extension, 54.4% of patients had controlled serum phosphate. After discontinuation of calcium carbonate and initiation of lanthanum carbonate, the hypercalcemia incidence was 2.7%, compared with 20.2% during the double-blind phase. Calcium x phosphate product was maintained at an acceptable level. Lanthanum carbonate was well tolerated; adverse events were mild/moderate and mainly gastrointestinal.

Conclusions: Lanthanum carbonate maintains effectiveness with continued tolerability for up to 3 years.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Calcium / blood
  • Calcium Carbonate / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Hypercalcemia / drug therapy
  • Hypercalcemia / etiology
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / therapy
  • Lanthanum / adverse effects
  • Lanthanum / therapeutic use*
  • Male
  • Middle Aged
  • Phosphates / blood*
  • Renal Dialysis*
  • Treatment Outcome


  • Phosphates
  • lanthanum carbonate
  • Lanthanum
  • Calcium Carbonate
  • Calcium