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, 9 (3), 365-76

Drosophila Exocyst Components Sec5, Sec6, and Sec15 Regulate DE-Cadherin Trafficking From Recycling Endosomes to the Plasma Membrane

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Drosophila Exocyst Components Sec5, Sec6, and Sec15 Regulate DE-Cadherin Trafficking From Recycling Endosomes to the Plasma Membrane

Johanna Langevin et al. Dev Cell.

Abstract

The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane. Furthermore, Rab11 and Armadillo interact with the exocyst components Sec15 and Sec10, respectively. Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located.

Comment in

  • Recycling polarity.
    Somers WG, Chia W. Somers WG, et al. Dev Cell. 2005 Sep;9(3):312-3. doi: 10.1016/j.devcel.2005.08.007. Dev Cell. 2005. PMID: 16139221 Review.

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