Capillary hemangioblastoma of soft tissue: report of a case and review of the literature

Hum Pathol. 2005 Oct;36(10):1135-9. doi: 10.1016/j.humpath.2005.07.003. Epub 2005 Sep 8.

Abstract

Capillary hemangioblastoma (CH) is a tumor of unknown histogenesis that arises primarily in the posterior cranial fossa, either as a sporadic event or in association with von Hippel-Lindau disease. To date, only 6 examples of a tumor with morphological features of CH arising in the somatic soft tissues have been documented in case reports and small series, and 3 of these tumors were associated with a peripheral nerve. Herein, we report a case of CH arising in the gastrocnemius muscle and not associated with a peripheral nerve in a 53-year-old woman with no clinical stigmata or family history of von Hippel-Lindau disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antigens, CD34 / metabolism
  • Black People / genetics
  • Cerebellar Neoplasms / diagnosis
  • Cerebellar Neoplasms / diagnostic imaging
  • Cerebellar Neoplasms / genetics
  • Cerebellar Neoplasms / pathology*
  • Cerebellar Neoplasms / surgery
  • Cerebellar Neoplasms / ultrastructure
  • Factor XIIIa / metabolism
  • Female
  • Follow-Up Studies
  • Hemangioblastoma / diagnosis
  • Hemangioblastoma / diagnostic imaging
  • Hemangioblastoma / genetics
  • Hemangioblastoma / pathology*
  • Hemangioblastoma / surgery
  • Hemangioblastoma / ultrastructure
  • Humans
  • Immunohistochemistry
  • Inhibins / metabolism
  • Magnetic Resonance Imaging
  • Middle Aged
  • Muscle, Skeletal / diagnostic imaging
  • Muscle, Skeletal / pathology*
  • Muscle, Skeletal / surgery
  • Muscle, Skeletal / ultrastructure
  • Phosphopyruvate Hydratase / metabolism
  • Platelet Endothelial Cell Adhesion Molecule-1 / metabolism
  • Radiography
  • S100 Proteins / metabolism
  • Stromal Cells / pathology
  • Stromal Cells / ultrastructure
  • Time Factors
  • Treatment Outcome
  • Vimentin / metabolism

Substances

  • Antigens, CD34
  • Platelet Endothelial Cell Adhesion Molecule-1
  • S100 Proteins
  • Vimentin
  • inhibin-alpha subunit
  • Inhibins
  • Factor XIIIa
  • Phosphopyruvate Hydratase