RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins

Cell Signal. 2006 May;18(5):579-91. doi: 10.1016/j.cellsig.2005.08.010. Epub 2005 Oct 13.


The intracellular regulator of G protein signalling (RGS) proteins were first identified as GTPase activating proteins (GAPs) for heterotrimeric G proteins, however, it was later found that they can also regulate G protein-effector interactions in other ways that are still not well understood. There is increasing evidence that some of the effects of RGS proteins occur due to their ability to interact with multiprotein signalling complexes. In this review, we will discuss recent evidence that supports the idea that RGS proteins can bind to proteins other than Galpha, such as G protein coupled receptors (GPCRs, e.g. muscarinic, dopaminergic, adrenergic, angiotensin, interleukin and opioid receptors) and effectors (e.g. adenylyl cyclase, GIRK channels, PDEgamma, PLC-beta and Ca(2+) channels). Furthermore, we will investigate novel RGS binding partners (e.g. GIPC, spinophilin, 14-3-3) that underlie the formation of signalling scaffolds or govern RGS protein availability and/or activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 14-3-3 Proteins / metabolism
  • 3',5'-Cyclic-GMP Phosphodiesterases / metabolism
  • Adenylyl Cyclases / metabolism
  • Animals
  • Calcium Channels / metabolism
  • Calmodulin / metabolism
  • G Protein-Coupled Inwardly-Rectifying Potassium Channels / metabolism
  • Guanylate Cyclase / metabolism
  • Isoenzymes / metabolism
  • Microfilament Proteins / metabolism
  • Nerve Tissue Proteins / metabolism
  • Phospholipase C beta
  • RGS Proteins / metabolism*
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction / physiology*
  • Type C Phospholipases / metabolism


  • 14-3-3 Proteins
  • Calcium Channels
  • Calmodulin
  • G Protein-Coupled Inwardly-Rectifying Potassium Channels
  • Isoenzymes
  • Microfilament Proteins
  • Nerve Tissue Proteins
  • RGS Proteins
  • Receptors, G-Protein-Coupled
  • neurabin
  • Type C Phospholipases
  • Phospholipase C beta
  • 3',5'-Cyclic-GMP Phosphodiesterases
  • Adenylyl Cyclases
  • Guanylate Cyclase