Genetic Susceptibility to Type 1 Diabetes

Curr Opin Immunol. 2005 Dec;17(6):601-8. doi: 10.1016/j.coi.2005.09.013. Epub 2005 Oct 13.

Abstract

The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been substantiated. Future genome-wide association studies will reveal more loci, each providing a piece to the genetic puzzle of autoimmune disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • Antigens, Differentiation / genetics
  • CTLA-4 Antigen
  • Diabetes Mellitus, Type 1 / genetics*
  • Genetic Linkage
  • Genetic Predisposition to Disease*
  • Humans
  • Insulin / genetics
  • Interleukin-2 Receptor alpha Subunit
  • Major Histocompatibility Complex
  • Mice
  • Mice, Inbred NOD
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • Protein Tyrosine Phosphatases / genetics
  • Receptors, Interleukin / genetics

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Ctla4 protein, mouse
  • IL2RA protein, human
  • Il2ra protein, mouse
  • Insulin
  • Interleukin-2 Receptor alpha Subunit
  • Receptors, Interleukin
  • PTPN22 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • Protein Tyrosine Phosphatases
  • Ptpn22 protein, mouse