The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection

Adv Immunol. 2005;88:235-65. doi: 10.1016/S0065-2776(05)88007-1.

Abstract

The onset of type 1 diabetes mellitus (T1DM) is directly linked to the expression of class II MHC molecules. The NOD mouse, which is an excellent animal model for the human disease, expresses the I-Ag7 molecule that shares many features with the human diabetogenic class II MHC alleles. In this review, the structural, biochemical, and biological properties of the I-Ag7 molecules and how they relate to onset of diabetes is discussed. In particular, the focus is on the unique properties of peptide selection by I-Ag7 that reveal the preferred binding motif of diabetogenic MHC molecules and its role in display of peptides derived from islet beta cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Binding Sites
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / metabolism*
  • Diabetes Mellitus, Type 1 / pathology
  • Disease Models, Animal
  • Disease Susceptibility
  • HLA-DQ Antigens / chemistry
  • HLA-DQ Antigens / genetics
  • HLA-DQ Antigens / immunology
  • HLA-DQ Antigens / metabolism*
  • Histocompatibility Antigens Class II / chemistry
  • Histocompatibility Antigens Class II / genetics
  • Histocompatibility Antigens Class II / immunology
  • Histocompatibility Antigens Class II / metabolism*
  • Humans
  • Islets of Langerhans / immunology
  • Islets of Langerhans / metabolism*
  • Islets of Langerhans / pathology
  • Mice
  • Mice, Inbred NOD
  • Peptide Fragments
  • Protein Binding / immunology
  • Protein Interaction Domains and Motifs / immunology

Substances

  • HLA-DQ Antigens
  • HLA-DQ8 antigen
  • Histocompatibility Antigens Class II
  • I-A g7 antigen
  • Peptide Fragments