Radical medicine: treating ageing to cure disease

Nat Rev Mol Cell Biol. 2005 Dec;6(12):971-6. doi: 10.1038/nrm1763.


The incidence of many diseases rises sharply with age. Although clearly separable, ageing and certain age-related diseases might share common mechanisms. Cellular metabolism and subsequent generation of reactive oxygen species might contribute both to the rate at which we age and to our susceptibility to numerous chronic diseases, therefore therapies that directly target the ageing process might provide new ways to treat human diseases.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Aging / metabolism*
  • Amyotrophic Lateral Sclerosis / metabolism
  • Animals
  • Cardiovascular Diseases / metabolism
  • Humans
  • Neoplasms / metabolism
  • Reactive Oxygen Species / metabolism*
  • Superoxide Dismutase / drug effects
  • Superoxide Dismutase / metabolism*
  • Therapeutics / trends*


  • Reactive Oxygen Species
  • Superoxide Dismutase