Regulatory networks in embryo-derived pluripotent stem cells

Nat Rev Mol Cell Biol. 2005 Nov;6(11):872-84. doi: 10.1038/nrm1744.


Mammalian development requires the specification of over 200 cell types from a single totipotent cell. Investigation of the regulatory networks that are responsible for pluripotency in embryo-derived stem cells is fundamental to understanding mammalian development and realizing therapeutic potential. Extracellular signals and second messengers modulate cell-autonomous regulators such as OCT4, SOX2 and Nanog in a combinatorial complexity. Knowledge of this circuitry might reveal how to achieve phenotypic changes without the genetic manipulation of Oct4, Nanog and other toti/pluripotency-associated genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism*
  • Embryo, Mammalian / cytology*
  • Mice
  • Pluripotent Stem Cells / metabolism*
  • Signal Transduction* / genetics
  • Transcription Factors / metabolism*


  • Transcription Factors