Evaluation of Coleman lipostructure for treatment of facial lipoatrophy in patients with human immunodeficiency virus and parameters associated with the efficiency of this technique

Arch Dermatol. 2005 Oct;141(10):1220-4. doi: 10.1001/archderm.141.10.1220.


Objective: To evaluate the efficiency of Coleman lipostructure in patients infected with human immunodeficiency virus (HIV).

Design: Open-label study and survey.

Setting: Ambulatory dermatosurgery department of a university hospital.

Patients: Thirty-three consecutive HIV-infected patients undergoing Coleman lipostructure between 2000 and 2001.

Interventions: Clinical examination, blood tests, and standardized photographs at baseline and 1 year after the lipostructure.

Mean outcome measures: Efficiency was assessed by the agreement of 3 independent medical specialists on facial lipodystrophy improvement after surgery and by patient satisfaction.

Results: Facial lipoatrophy was improved in 12 patients (36%; 95% confidence interval, 20%-52%) as judged by all 3 evaluators. Quantity of fat injected (P = .01) and a low serum triglyceride level before surgery (P = .03) were significantly associated with improvement of facial lipoatrophy. Of the 33 patients, 14 (43%) were very satisfied, 17 (50%) were partly satisfied, and 27 (81%) had a better quality of life. The most common comment was that the patient looked better and appeared less ill.

Conclusion: Our 1-year evaluation of Coleman lipostructure for correction of facial lipoatrophy in HIV-infected patients proved the efficiency of this treatment when measured conservatively by agreement on improvement by 3 independent specialists and demonstrated a patient satisfaction rate of 93%.

Publication types

  • Clinical Trial

MeSH terms

  • Adipose Tissue / transplantation*
  • Adult
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Female
  • HIV Infections / drug therapy*
  • Humans
  • Injections, Subcutaneous
  • Lipodystrophy / chemically induced*
  • Lipodystrophy / pathology
  • Lipodystrophy / surgery*
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Transplantation, Autologous / adverse effects
  • Treatment Outcome