G proteins in development

Nat Rev Mol Cell Biol. 2005 Sep;6(9):689-701. doi: 10.1038/nrm1716.


The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and various ion channels. The convergence of developmental biology with cell signalling has now revealed overlaps in which G proteins mediate complex pathways in embryonic development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Developmental Biology
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Models, Biological
  • Morphogenesis / physiology*
  • Protein Subunits / metabolism
  • Receptors, G-Protein-Coupled / metabolism
  • Second Messenger Systems / physiology*


  • Protein Subunits
  • Receptors, G-Protein-Coupled
  • GTP-Binding Proteins