Two-way traffic: centrosomes and the cell cycle

Nat Rev Mol Cell Biol. 2005 Sep;6(9):743-8. doi: 10.1038/nrm1712.

Abstract

The well recognized activities of the mammalian centrosome--microtubule nucleation, duplication, and organization of the primary cilium--are under the control of the cell cycle. However, the centrosome is more than just a follower of the cell cycle; it can also be essential for the cell to transit G1 and enter S phase. How the centrosome influences G1 progression is a mystery.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Centrosome / metabolism*
  • Centrosome / ultrastructure
  • Microsurgery
  • Signal Transduction / physiology