Stellate ganglion blockade provides relief from menopausal hot flashes: a case report series

J Womens Health (Larchmt). 2005 Oct;14(8):737-41. doi: 10.1089/jwh.2005.14.737.


Objective: To investigate whether standard C6 stellate ganglion blockade (SGB) might provide relief from hot flashes associated with menopause.

Methods: Six women were referred for severe menopausal hot flashes and elected to undergo standard SGB (5 ml 0.375% Marcaine, Abbott Labs, Abbott Park, IL) to evaluate a novel intervention for hot flash relief. Hot flashes were assessed by self-reporting before and after stellate ganglion block.

Results: Initial SGB (SGB1) was successful in all 6 subjects, as evidenced by a positive Horner's syndrome and anhydrosis. Successful SGB caused complete alleviation of hot flashes for times ranging from 2 to 5 weeks. Patients returned for follow-up SGB after mild hot flashes returned. A second SGB produced additional asymptomatic periods of relief ranging from 4 to 18 weeks. In each case, repeated block provided hot flash relief equal to or greater than that of the initial block. Two patients who submitted for a third SGB reported 15 and 48 weeks of relief.

Conclusion: Successful SGB appears to be related to relief of hot flashes. Repeat SGB results in efficacious multiple week relief of severe hot flashes associated with menopause.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthesia, Local* / methods
  • Anesthetics, Local / administration & dosage*
  • Autonomic Nerve Block* / methods
  • Female
  • Hot Flashes / drug therapy*
  • Hot Flashes / prevention & control
  • Humans
  • Menopause / drug effects
  • Middle Aged
  • Stellate Ganglion / drug effects*
  • Treatment Outcome


  • Anesthetics, Local