Tadalafil reversal of sexual dysfunction caused by serotonin enhancing medications in women

J Sex Marital Ther. 2006 Jan-Feb;32(1):1-3. doi: 10.1080/00926230500229079.


Sexual dysfunction is a common side effect of many antidepressants, especially those that increase serotonin. Many strategies have been reported to assist patients in minimizing impairment, with variable degrees of success. One of the newer approaches is to augment with phosphodiesterase type-5 inhibitors. Our report using the most recently released agent in this class, tadalafil is the first demonstrating potential benefit in women. We report here of three women who derived benefit from using 20 mg of tadalafil before anticipated sexual activity to reverse medication-induced sexual dysfunction. Tadalafil utility was maintained over time and was well tolerated.

Publication types

  • Case Reports

MeSH terms

  • Carbolines / administration & dosage*
  • Coitus
  • Female
  • Humans
  • Libido / drug effects
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Sexual Dysfunction, Physiological / chemically induced*
  • Sexual Dysfunction, Physiological / drug therapy*
  • Tadalafil
  • Vasodilator Agents / administration & dosage*
  • Women's Health


  • Carbolines
  • Serotonin Uptake Inhibitors
  • Vasodilator Agents
  • Tadalafil