Abstract
[reaction: see text] Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Transport Systems / chemical synthesis*
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Amino Acid Transport Systems / chemistry
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Amino Acid Transport Systems / pharmacokinetics
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Cell Line
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Dendrimers / chemical synthesis*
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Dendrimers / chemistry
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Dendrimers / pharmacokinetics
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / pharmacokinetics
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Guanidine / chemistry*
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Humans
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Lymphocytes / drug effects
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Lymphocytes / metabolism
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Molecular Structure
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Polymers / chemical synthesis*
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Polymers / chemistry
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Polymers / pharmacokinetics
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Protein Transport / drug effects
Substances
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Amino Acid Transport Systems
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Dendrimers
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Fluorescent Dyes
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Polymers
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Guanidine