Co-inhibitory role of T-cell-associated B7-H1 and B7-DC in the T-cell immune response

Immunol Lett. 2006 Feb 15;102(2):222-8. doi: 10.1016/j.imlet.2005.09.007. Epub 2005 Oct 5.


B7-H1 and B7-DC expressed on antigen-presenting cells inhibit the T-cell response via the PD-1 counter-receptor on T cells, and co-stimulate T-cell immunity under certain conditions via an unidentified co-stimulatory receptor. However, little is known about the functional consequence of T-cell-associated B7-H1 or B7-DC in the T-cell immune response. Therefore, we evaluated the physiological role of B7-H1 and B7-DC expressed on T cells in terms of cell proliferation and cytokine production by alloreactive T cells. We found that PD-1, B7-H1, and B7-DC were up-regulated in alloreactive CD4(+) and CD8(+) T cells in vitro and in vivo. In the alloreactive T-T model, blockade of the B7-H1:PD-1 or B7-DC:PD-1 pathways significantly increased the proliferation, and IFN-gamma and IL-2 production of alloreactive T cells, although it did not affect the production of other cytokines, including IL-4, IL-10, and IL-12. The data indicate that T-cell-associated B7-H1 and B7-DC negatively regulate the T-cell response via the T-T interaction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation / biosynthesis
  • Antigens, Differentiation / genetics
  • Antigens, Differentiation / immunology
  • Antigens, Surface / genetics
  • Antigens, Surface / immunology
  • B7-1 Antigen / biosynthesis
  • B7-1 Antigen / genetics
  • B7-1 Antigen / immunology*
  • B7-1 Antigen / metabolism
  • B7-H1 Antigen
  • Cell Proliferation
  • Cytokines / metabolism*
  • Membrane Glycoproteins / immunology*
  • Membrane Glycoproteins / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Peptides / immunology*
  • Peptides / metabolism
  • Programmed Cell Death 1 Ligand 2 Protein
  • T-Lymphocytes / immunology*


  • Antigens, Differentiation
  • Antigens, Surface
  • B7-1 Antigen
  • B7-H1 Antigen
  • Cd274 protein, mouse
  • Cytokines
  • Membrane Glycoproteins
  • Pdcd1lg2 protein, mouse
  • Peptides
  • Programmed Cell Death 1 Ligand 2 Protein