Cardiovascular morbidity and mortality in COPD

Chest. 2005 Oct;128(4):2640-6. doi: 10.1378/chest.128.4.2640.


Study objective: COPD and cardiovascular disease (CVD) share common risk factors. We undertook to estimate rates of hospitalization and death from CVD in COPD patients relative to the general population.

Design and setting: A cohort of patients > or = 55 years old receiving a first treatment for COPD between 1990 and 1997 was formed from the Saskatchewan Health databases. All hospitalizations and deaths between cohort entry and the end of 1999 were identified.

Results: The cohort included 5,648 individuals and generated 23,426 person-years (PY) of follow-up. The overall rates of cardiovascular morbidity and mortality were 177.2 and 41 per 1,000 PY, respectively. Cardiovascular morbidity and mortality rates were higher in the COPD cohort than in the general population (standardized rate ratios of 1.9 and 2.0, respectively). More hospitalizations for CVD than for COPD itself were reported. Among CVDs, heart failure represented the most frequent cause of hospitalization (58.8 per 1,000 PY). CVD and more specifically ischemic heart disease (19.6 per 1,000 PY) were reported as a more frequent cause of death than COPD itself (15.5 per 1,000 PY).

Conclusion: CVD is more frequent in COPD patients than in the general population and may represent a burden greater than that of lung disease itself.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / mortality
  • Cerebrovascular Disorders / epidemiology
  • Cerebrovascular Disorders / mortality
  • Cohort Studies
  • Comorbidity
  • Databases, Factual
  • Female
  • Heart Failure / epidemiology
  • Heart Failure / mortality
  • Humans
  • Male
  • Myocardial Infarction / epidemiology
  • Myocardial Infarction / mortality
  • Myocardial Ischemia / epidemiology
  • Myocardial Ischemia / mortality
  • Pulmonary Disease, Chronic Obstructive / mortality
  • Pulmonary Disease, Chronic Obstructive / physiopathology*
  • Saskatchewan / epidemiology