O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks

J Cell Biochem. 2006 Jan 1;97(1):71-83. doi: 10.1002/jcb.20676.


O-GlcNAc is an ubiquitous post-translational protein modification consisting of a single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins. Recent work has begun to uncover the functional roles of O-GlcNAc in cellular processes. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. This review will focus on recent work involving O-GlcNAc in sensing the environment and regulating signaling cascades.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylglucosamine / metabolism*
  • Animals
  • Humans
  • Protein Processing, Post-Translational*
  • Signal Transduction*
  • Transcription, Genetic


  • Acetylglucosamine