Intracellular Survival Mechanisms of Francisella Tularensis, a Stealth Pathogen

Microbes Infect. 2006 Feb;8(2):561-7. doi: 10.1016/j.micinf.2005.08.001. Epub 2005 Sep 15.


Research on the highly virulent and contagious, facultative intracellular bacterium Francisella tularensis has come into the limelight recently, but still little is known regarding its virulence mechanisms. This review summarizes recent studies on its intramacrophage survival mechanisms, some of which appear to be novel.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endothelial Cells / microbiology*
  • Francisella tularensis / genetics
  • Francisella tularensis / growth & development*
  • Francisella tularensis / pathogenicity*
  • Humans
  • Macrophages / microbiology*
  • Mice
  • Tularemia / microbiology
  • Virulence