Effect of EGF on the corneal wound healing of alloxan diabetic mice

Exp Eye Res. 1992 Apr;54(4):519-24. doi: 10.1016/0014-4835(92)90130-k.


We identified the local treatment effect of epidermal growth factor on corneal wound healing of alloxan diabetic mice. The corneal wounds were induced by 0.5 M NaOH solution on the corneal surfaces of the diabetic and non-diabetic groups. The local epidermal growth factor solution (100 ng ml-1) was dropped in 5-microliters aliquots into the eye twice a day. The corneal wounds were measured daily for 15 days and examined histologically at the end of 15th day of experimental period. The results indicated that topical epidermal growth factor treatment of diabetic and non-diabetic mice greatly improved the incidence of healing of wounded corneas.

MeSH terms

  • Administration, Topical
  • Animals
  • Cornea / pathology
  • Corneal Injuries*
  • Diabetes Mellitus, Experimental / physiopathology*
  • Epidermal Growth Factor / administration & dosage
  • Epidermal Growth Factor / pharmacology*
  • Female
  • Male
  • Mice
  • Time Factors
  • Wound Healing / drug effects*


  • Epidermal Growth Factor