The second human beta B2-crystallin gene is a pseudogene

Exp Eye Res. 1992 May;54(5):803-6. doi: 10.1016/0014-4835(92)90036-r.

Abstract

Comparison of the partial sequences of the human beta B2-1- and beta B2-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human beta B2-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the beta B2-2-crystallin gene could be detected in the human lens. These data suggest that the human beta B2-2-crystallin gene is a pseudogene.

MeSH terms

  • Base Sequence
  • Blotting, Northern
  • Crystallins / genetics*
  • Exons / physiology
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Oligonucleotide Probes
  • Pseudogenes / physiology*

Substances

  • Crystallins
  • Oligonucleotide Probes