Leptin sensitivity in skeletal muscle is modulated by diet and exercise

Exerc Sport Sci Rev. 2005 Oct;33(4):189-94. doi: 10.1097/00003677-200510000-00007.


Leptin reduces intracellular lipid stores and improves insulin sensitivity. Thus, the development of leptin resistance in obesity may be an early event leading to elevated intramuscular lipids and insulin resistance. Recent data indicate that obesity-causing high-fat diets lead to leptin resistance in muscle, whereas supplementation with dietary fish oil and aerobic training can partially reverse this resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dietary Fats / metabolism*
  • Exercise / physiology*
  • Fatty Acids / metabolism
  • Humans
  • Leptin / physiology*
  • Muscle, Skeletal / physiology*
  • Obesity / physiopathology


  • Dietary Fats
  • Fatty Acids
  • Leptin