Virulence phenotypes of Shigella flexneri 2a avirulent mutant 24570 can be complemented by the plasmid-coded positive regulator virF gene

M S Qi; H Yoshikura; H Watanabe

doi:10.1111/j.1574-6968.1992.tb05264.x

Virulence phenotypes of Shigella flexneri 2a avirulent mutant 24570 can be complemented by the plasmid-coded positive regulator virF gene

FEMS Microbiol Lett. 1992 May 1;71(3):217-21. doi: 10.1111/j.1574-6968.1992.tb05264.x.

Authors

M S Qi¹, H Yoshikura, H Watanabe

Affiliation

¹ Department of Bacteriology, National Institute of Health, Tokyo, Japan.

PMID: 1624118
DOI: 10.1111/j.1574-6968.1992.tb05264.x

Abstract

Avirulent mutation of an opaque colony variant of Shigella flexneri 2a designated 24570 has been believed to be linked with the glpK locus of the chromosome. However, avirulent phenotypes of the 24570 strain could be complemented by the invasion plasmid-coded virF gene, a positive regulator for invasion genes. The 24570 strain had a DNA structural alteration upstream of the virF gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Bacterial / analysis
Base Sequence
DNA, Bacterial / genetics*
Genes, Regulator / genetics*
Genetic Complementation Test
Molecular Sequence Data
Mutation / genetics
Plasmids / genetics
Polymerase Chain Reaction
Serotyping
Shigella flexneri / genetics*
Shigella flexneri / pathogenicity
Virulence / genetics

Substances

Antigens, Bacterial
DNA, Bacterial