Contributions of the amygdala to emotion processing: from animal models to human behavior

Neuron. 2005 Oct 20;48(2):175-87. doi: 10.1016/j.neuron.2005.09.025.


Research on the neural systems underlying emotion in animal models over the past two decades has implicated the amygdala in fear and other emotional processes. This work stimulated interest in pursuing the brain mechanisms of emotion in humans. Here, we review research on the role of the amygdala in emotional processes in both animal models and humans. The review is not exhaustive, but it highlights five major research topics that illustrate parallel roles for the amygdala in humans and other animals, including implicit emotional learning and memory, emotional modulation of memory, emotional influences on attention and perception, emotion and social behavior, and emotion inhibition and regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amygdala / physiology*
  • Animals
  • Attention / physiology
  • Behavior / physiology*
  • Brain Mapping
  • Emotions / physiology*
  • Fear
  • Humans
  • Inhibition, Psychological
  • Models, Animal*
  • Perception / physiology