Nucleotide analogues to investigate RNA structure and function

Curr Opin Chem Biol. 2005 Dec;9(6):585-93. doi: 10.1016/j.cbpa.2005.10.009. Epub 2005 Oct 20.


RNA plays an essential cellular role in nearly every aspect of the transmission and expression of genetic information, including regulatory roles that have significance for cellular development. Access to RNA bearing synthetic modifications has allowed biological chemists to probe deep into the inner workings of cellular processes. Here, we describe recent advances in harnessing the power of nucleotide analogues to obtain mechanistic and biological insights into RNA structure, function and dynamics.

Publication types

  • Review

MeSH terms

  • Catalysis
  • Crystallography, X-Ray
  • Metals / chemistry
  • Models, Biological
  • Nucleic Acid Conformation
  • Oligoribonucleotides / chemistry*
  • RNA / chemistry*
  • RNA / physiology*
  • RNA, Catalytic / chemistry
  • RNA, Catalytic / metabolism


  • Metals
  • Oligoribonucleotides
  • RNA, Catalytic
  • RNA