Body-size regulation: combining genetics and physiology

Curr Biol. 2005 Oct 25;15(20):R825-7. doi: 10.1016/j.cub.2005.10.006.

Abstract

New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Body Size / physiology*
  • Drosophila / genetics
  • Drosophila / growth & development*
  • Drosophila Proteins / metabolism
  • Ecdysone / metabolism*
  • Insulin / metabolism*
  • Larva / growth & development
  • PTEN Phosphohydrolase / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Signal Transduction / physiology*

Substances

  • Drosophila Proteins
  • Insulin
  • Ecdysone
  • Phosphatidylinositol 3-Kinases
  • PTEN Phosphohydrolase
  • PTEN protein, Drosophila