Clindamycin in dentistry: more than just effective prophylaxis for endocarditis?

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Nov;100(5):550-8. doi: 10.1016/j.tripleo.2005.02.086.


Clindamycin is a broad-spectrum antibiotic with activity against aerobic, anaerobic, and beta-lactamase-producing pathogens. This antibiotic has been used for many years as prophylactic treatment during dental procedures to prevent endocarditis. However, the spectrum and susceptibility of the bacteria species involved in dental infections indicate that clindamycin would also be an effective treatment option for these conditions. In addition to its antiinfective properties, clindamycin has high oral absorption, significant tissue penetration, including penetration into bone, and stimulatory effects on the host immune system. This review discusses the microbiologic and clinical evidence supporting the efficacy and safety of clindamycin for the successful management of dental infections.

MeSH terms

  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use*
  • Antibiotic Prophylaxis
  • Bacteria, Anaerobic / drug effects
  • Clindamycin / pharmacokinetics
  • Clindamycin / pharmacology*
  • Clindamycin / therapeutic use*
  • Dental Implants / adverse effects
  • Dental Pulp Diseases / drug therapy
  • Dental Pulp Diseases / microbiology
  • Drug Resistance, Bacterial
  • Endocarditis, Bacterial / prevention & control
  • Focal Infection, Dental / drug therapy*
  • Focal Infection, Dental / microbiology*
  • Gram-Negative Bacteria / drug effects
  • Humans
  • Periodontitis / drug therapy
  • Periodontitis / etiology
  • Periodontitis / microbiology


  • Anti-Bacterial Agents
  • Dental Implants
  • Clindamycin