PEGylation, successful approach to drug delivery

Drug Discov Today. 2005 Nov 1;10(21):1451-8. doi: 10.1016/S1359-6446(05)03575-0.


PEGylation defines the modification of a protein, peptide or non-peptide molecule by the linking of one or more polyethylene glycol (PEG) chains. This polymer is non-toxic, non-immunogenic, non-antigenic, highly soluble in water and FDA approved. The PEG-drug conjugates have several advantages: a prolonged residence in body, a decreased degradation by metabolic enzymes and a reduction or elimination of protein immunogenicity. Thanks to these favorable properties, PEGylation now plays an important role in drug delivery, enhancing the potentials of peptides and proteins as therapeutic agents.

Publication types

  • Review

MeSH terms

  • Drug Carriers
  • Drug Delivery Systems / methods*
  • Peptides / administration & dosage*
  • Peptides / chemistry
  • Polyethylene Glycols / chemistry*
  • Proteins / administration & dosage*
  • Proteins / chemistry


  • Drug Carriers
  • Peptides
  • Proteins
  • Polyethylene Glycols