Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Dec 16;338(2):771-6.
doi: 10.1016/j.bbrc.2005.10.013. Epub 2005 Oct 13.

A Functional Link Between Disrupted-In-Schizophrenia 1 and the Eukaryotic Translation Initiation Factor 3

Affiliations

A Functional Link Between Disrupted-In-Schizophrenia 1 and the Eukaryotic Translation Initiation Factor 3

Fumiaki Ogawa et al. Biochem Biophys Res Commun. .

Erratum in

  • Biochem Biophys Res Commun. 2006 Jul 7;345(3):1273

Abstract

Disrupted-In-Schizophrenia 1 (DISC1) was identified as a candidate gene for schizophrenia. DISC1 is disrupted by a balanced t(1;11)(q42.1;q14.3) translocation segregating with schizophrenia and related psychiatric illness in a large Scottish family. Here, we show that DISC1 interacts via its globular domain with the p40 subunit of the eukaryotic translation initiation factor 3. Furthermore, we found that overexpression of DISC1 in SH-SY5Y cells induces the assembly of eIF3- and TIA-1-positive stress granules (SGs), discrete cytoplasmic granules formed in response to environmental stresses. Our findings suggest that DISC1 may function as a translational regulator and may be involved in stress response.

Similar articles

See all similar articles

Cited by 21 articles

See all "Cited by" articles

LinkOut - more resources

Feedback