High frequency of mutation of epidermal growth factor receptor in lung adenocarcinoma in Thailand

Cancer Lett. 2006 Aug 8;239(2):292-7. doi: 10.1016/j.canlet.2005.08.029. Epub 2005 Oct 21.

Abstract

Recent reports have suggested influences of racial difference on the frequency of mutation of EGFR in lung cancer. We therefore sought to characterize the frequency and pattern of mutation of EGFR in lung adenocarcinoma in Thai patients. Overall, EGFR catalytic domain mutations were detected in 35/61 (57.4%). We found 29/60 (48.3%) of exon 19 deletions, 5/54 (9.3%) of exon 21 point mutations, and 1/54 (1.9%) of double-mutation of both exons. The presence of these mutations was significantly associated with non-smoking habit. In summary, we report a strikingly high prevalence of mutation of EGFR in Thai lung adenocarcinoma, which may explain the high response rate to the treatment with TKI among Asian populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Amino Acid Sequence
  • Base Sequence
  • ErbB Receptors / genetics*
  • Exons
  • Humans
  • Lung Neoplasms / genetics*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Thailand

Substances

  • ErbB Receptors