Sleep-related breathing disorders are a heterogeneous group of conditions that may be associated with alterations in the structure of sleep, in sleep quality, and in gas exchange during sleep. Obstructive sleep apnea represents the most frequent cause of sleep-related breathing disorders, which encompass a diversity of conditions that either complicate coexisting disease or present as primary disorders. Many of these disorders have consequences during both sleep and wakefulness and may produce substantial burden of symptoms and disease in untreated individuals.