Deoxymulundocandin--a New Echinocandin Type Antifungal Antibiotic

J Antibiot (Tokyo). 1992 May;45(5):618-23. doi: 10.7164/antibiotics.45.618.

Abstract

A new echinocandin type antifungal antibiotic, deoxymulundocandin, C48H77N7O15, was isolated from the culture filtrate and mycelia of a fungal culture, Aspergillus sydowii (Bainier and Sartory) Thom and Church var. nov. mulundensis Roy (Culture No. Y-30462). The structure was established by comparative GC-MS analyses of the derivatized acid hydrolysates of deoxymulundocandin and mulundocandin as well as by the high field NMR experiments (COSY, NOESY and DEPT).

Publication types

  • Comparative Study

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Aspergillus / chemistry*
  • Chromatography, High Pressure Liquid
  • Echinocandins
  • Gas Chromatography-Mass Spectrometry
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification
  • Peptides, Cyclic / pharmacology

Substances

  • Antifungal Agents
  • Echinocandins
  • Peptides, Cyclic
  • deoxymulundocandin
  • mulundocandin