Bystin in perineural invasion of prostate cancer

Prostate. 2006 Feb 15;66(3):266-72. doi: 10.1002/pros.20323.


Background: Bystin, Trophinin, and Tastin are component proteins of an adhesion molecule complex that plays a crucial role in the initial attachment of the embryo to the uterus.

Methods: Profiling of genes differentially expressed in the perineural invasion (PNI) in vitro model by gene microarray analysis showed overexpression of bystin in prostate cancer cells co-cultured with nerves. Validation was performed at the RNA levels using quantitative PCR.

Results: Bystin is overexpressed in cells co-cultured with nerves. Bystin is also present in human prostatic carcinoma (PCa) cells in PNI location in increasing gradient. Bystin is present in the supernatant of the PNI co-culture.

Conclusions: Their adhesive and invasive functions in the trophoblast suggest that they might also play a role in perineural adhesion. Bystin is, therefore, an important therapeutic target for neurotropic cancers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Blotting, Western
  • Cell Adhesion Molecules / biosynthesis*
  • Cell Adhesion Molecules / genetics
  • Cell Line, Tumor
  • Coculture Techniques
  • Ganglia, Spinal
  • Humans
  • Male
  • Mice
  • Neoplasm Invasiveness
  • Oligonucleotide Array Sequence Analysis
  • Peripheral Nerves / pathology*
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology*
  • RNA, Neoplasm / chemistry
  • RNA, Neoplasm / genetics
  • Reverse Transcriptase Polymerase Chain Reaction


  • BYSL protein, human
  • Cell Adhesion Molecules
  • RNA, Neoplasm