Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression

BMC Psychiatry. 2005 Oct 24;5:38. doi: 10.1186/1471-244X-5-38.

Abstract

Background: The POU-domain transcription factor Oct-6 has been reported to be differentially expressed between schizophrenic and control post-mortem brains. In this study, we attempted to replicate this finding and to discover whether Oct-6 was also dysregulated in bipolar disorder and major depression.

Methods: Oct-6 mRNA and protein expression were determined by in-situ hybridization and immunohistochemistry respectively in sections of post-mortem brain.

Results: We did not observe any differences in Oct-6 expression between any of the groups under study. Oct-6 mRNA and protein was identically expressed in the hippocampal and cortical regions of most specimens in all groups, including controls.

Conclusion: Oct-6 is, therefore, unlikely to be a specific marker for any psychological disorder; rather its expression in controls suggests that it is normally expressed in most adult brains.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers
  • Bipolar Disorder / genetics
  • Bipolar Disorder / metabolism*
  • Brain Chemistry
  • Cause of Death
  • Cerebral Cortex / metabolism
  • Depressive Disorder, Major / genetics
  • Depressive Disorder, Major / metabolism*
  • Female
  • Frozen Sections
  • Gene Expression
  • Hippocampus / metabolism
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Male
  • Middle Aged
  • Octamer Transcription Factor-6 / genetics
  • Octamer Transcription Factor-6 / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Schizophrenia / genetics
  • Schizophrenia / metabolism*

Substances

  • Biomarkers
  • RNA, Messenger
  • Octamer Transcription Factor-6