Salivary gland function and glucose metabolic status

J Gerontol. 1992 Jul;47(4):M130-4. doi: 10.1093/geronj/47.4.m130.


To study the relationship between glucose metabolic status and salivary gland function in different-aged persons, subjects with diabetes mellitus (DM = 11), impaired glucose tolerance (IGT = 26), and controls (n = 26), aged 24 to 93, were examined in the oral physiology component of the Baltimore Longitudinal Study of Aging. All were generally healthy (except DM) and nonmedicated. The controls and subjects with IGT were classified using World Health Organization criteria, and diabetic status was assessed using Hb1Ac levels. Unstimulated and 2% citrate-stimulated parotid and submandibular salivary flow rates were collected, and subjective responses to questions about salivary hypofunction were evaluated. No statistically significant differences were observed between the three groups, nor between young and old subjects with altered glucose metabolism. These findings suggest that among well-controlled individuals with altered glucose metabolism, salivary gland function is not significantly impaired.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Diabetes Mellitus / physiopathology
  • Female
  • Glucose / metabolism*
  • Glucose Tolerance Test
  • Humans
  • Male
  • Middle Aged
  • Saliva / metabolism
  • Salivary Glands / metabolism*
  • Xerostomia / physiopathology


  • Glucose