Abstract
HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TITAGGG)4 human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acrolein / chemistry
-
Acrolein / pharmacology*
-
DNA / chemistry
-
Humans
-
Magnetic Resonance Spectroscopy
-
Models, Chemical
-
Nucleic Acid Conformation
-
Nucleic Acid Denaturation
-
Nucleic Acid Heteroduplexes
-
Oligonucleotides / chemistry*
-
Repetitive Sequences, Nucleic Acid
-
Spectrometry, Mass, Electrospray Ionization
-
Telomere / ultrastructure*
Substances
-
Nucleic Acid Heteroduplexes
-
Oligonucleotides
-
Acrolein
-
DNA