Effects of acrolein on the quadruplex forming d(TTAGGG)4 telomeric repeat sequence

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):447-50. doi: 10.1081/ncn-200059993.

Abstract

HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TITAGGG)4 human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrolein / chemistry
  • Acrolein / pharmacology*
  • DNA / chemistry
  • Humans
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Nucleic Acid Conformation
  • Nucleic Acid Denaturation
  • Nucleic Acid Heteroduplexes
  • Oligonucleotides / chemistry*
  • Repetitive Sequences, Nucleic Acid
  • Spectrometry, Mass, Electrospray Ionization
  • Telomere / ultrastructure*

Substances

  • Nucleic Acid Heteroduplexes
  • Oligonucleotides
  • Acrolein
  • DNA