Novel cyclosal nucleotides with reduced inhibitory potency toward human butyrylcholinesterase

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):519-22. doi: 10.1081/ncn-200061791.

Abstract

Two novel cycloSal-d4T monophosphates (d4TMPs) with increased steric demand have been synthesized via a new synthetic route. While 3-cyclohexyl-cycloSal d4TMP did not show a significantly reduced inhibitory potency toward human butyrylcholinesterase, the opposite was the case for the second novel pronucleotide, bis-(cycloSal-d4TMP).

MeSH terms

  • Antiviral Agents / pharmacology
  • Binding Sites
  • Butyrylcholinesterase / chemistry*
  • Chemistry, Pharmaceutical / methods
  • Cholinesterase Inhibitors / chemical synthesis*
  • Cholinesterase Inhibitors / pharmacology*
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Models, Chemical
  • Nucleotides / chemistry
  • Nucleotides / pharmacology*
  • Stereoisomerism
  • Temperature

Substances

  • Antiviral Agents
  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Nucleotides
  • Butyrylcholinesterase