Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70. doi: 10.1081/ncn-200060112.

Abstract

In order to improve the oral bioavailability of 2-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection.

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / pharmacology*
  • Chemistry, Pharmaceutical / methods*
  • Deoxycytidine / chemistry*
  • Deoxycytidine / pharmacology*
  • Drug Design
  • Hepacivirus / genetics*
  • Hepatitis C / drug therapy*
  • Hepatitis C / virology*
  • Humans
  • Models, Chemical
  • Prodrugs / chemistry
  • Prodrugs / pharmacology*
  • Pyrimidine Nucleosides / chemical synthesis*
  • Pyrimidine Nucleosides / pharmacology*

Substances

  • Antiviral Agents
  • Prodrugs
  • Pyrimidine Nucleosides
  • Deoxycytidine
  • valopicitabine