NMR assignments of territrems A, B, and C and the structure of MB2, the major metabolite of territrem B by rat liver microsomal fraction

J Nat Prod. 1992 Feb;55(2):251-5. doi: 10.1021/np50080a020.

Abstract

The 1H- and 13C-nmr assignments of territrems A, B, and C [1-3] were made by using nOe and 2D nmr techniques. Following the same methods, the structure of MB2 [4], the major product of territrem B incubated with rat liver microsomal fraction, was determined as a hydroxylation product at the pro S methyl group of C-4 of territrem B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hydroxylation
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Microsomes, Liver / metabolism*
  • Pyrans / analysis*
  • Rats

Substances

  • Pyrans
  • 4-hydroxymethyl-4-demethylterritrem B
  • territrem A
  • territrem B
  • territrem C