Effectiveness of anidulafungin in eradicating Candida species in invasive candidiasis

M A Pfaller; D J Diekema; L Boyken; S A Messer; S Tendolkar; R J Hollis; B P Goldstein

doi:10.1128/AAC.49.11.4795-4797.2005

Effectiveness of anidulafungin in eradicating Candida species in invasive candidiasis

Antimicrob Agents Chemother. 2005 Nov;49(11):4795-7. doi: 10.1128/AAC.49.11.4795-4797.2005.

Authors

M A Pfaller¹, D J Diekema, L Boyken, S A Messer, S Tendolkar, R J Hollis, B P Goldstein

Affiliation

¹ Medical Microbiology Division, C606 GH, Department of Pathology, Roy J. and A. Carver College of Medicine, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA. michael-pfaller@uiowa.edu

Abstract

In a phase 2 open-label, dose-ranging study in patients with candidemia, anidulafungin was effective in eradicating Candida albicans and other species of Candida. The anidulafungin MIC distribution showed that Candida albicans and C. glabrata were the most susceptible species and C. parapsilosis was the least susceptible species.

Publication types

Clinical Trial, Phase II

MeSH terms

Adult
Anidulafungin
Antifungal Agents / therapeutic use*
Candida / drug effects
Candidiasis / drug therapy*
Echinocandins
Humans
Microbial Sensitivity Tests
Peptides, Cyclic / therapeutic use*

Substances

Antifungal Agents
Echinocandins
Peptides, Cyclic
Anidulafungin