Review of major clinical trials with mycophenolate mofetil in cardiac transplantation

Transplantation. 2005 Oct 15;80(2 Suppl):S235-43. doi: 10.1097/


Over the past 10 years, the addition of mycophenolate mofetil (MMF) to combination immunosuppressive regimens in cardiac transplant patients has resulted in significant outcomes benefits. Randomized trials and other studies have demonstrated that the use of MMF is associated with a decreased risk of rejection and improved survival. This article will provide an overview of these trials, as well as those evaluating MMF in renal-sparing regimens and in pediatric cardiac transplant recipients. In addition, emerging evidence demonstrating that MMF may provide long-term benefits in reducing cardiac allograft vasculopathy and those evaluating the role of MMF therapeutic drug monitoring in cardiac transplant recipients will be discussed.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Azathioprine / therapeutic use
  • Calcineurin Inhibitors
  • Child
  • Clinical Trials as Topic
  • Cyclosporine / therapeutic use
  • Drug Monitoring
  • Drug Therapy, Combination
  • Graft Rejection / pathology
  • Graft Rejection / prevention & control*
  • Heart Transplantation* / adverse effects
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Kidney / drug effects
  • Kidney / physiology
  • Mycophenolic Acid / analogs & derivatives*
  • Mycophenolic Acid / therapeutic use


  • Adrenal Cortex Hormones
  • Calcineurin Inhibitors
  • Immunosuppressive Agents
  • Cyclosporine
  • Mycophenolic Acid
  • Azathioprine