Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

Nat Neurosci. 2005 Nov;8(11):1450-7. doi: 10.1038/nn1583.


Genetic variation may partially underlie complex personality and physiological traits--such as impulsivity, risk taking and stress responsivity--as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially affect the various stages of addiction, defined chronologically as initiation of drug use, regular drug use, addiction/dependence and potentially relapse. Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Comorbidity
  • Genetic Variation
  • Humans
  • Impulsive Behavior / genetics*
  • Models, Biological
  • Personality / genetics
  • Risk-Taking*
  • Stress, Physiological / genetics*
  • Substance-Related Disorders / epidemiology
  • Substance-Related Disorders / genetics*
  • Substance-Related Disorders / physiopathology