t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma

Genes Chromosomes Cancer. 2006 Feb;45(2):164-8. doi: 10.1002/gcc.20278.


Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosomes, Human, Pair 14*
  • Chromosomes, Human, Pair 3*
  • DNA Primers
  • Forkhead Transcription Factors / genetics*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Lymphoma, B-Cell / genetics*
  • Lymphoma, Large B-Cell, Diffuse / genetics*
  • Repressor Proteins / genetics*
  • Translocation, Genetic*


  • DNA Primers
  • FOXP1 protein, human
  • Forkhead Transcription Factors
  • Repressor Proteins