An emerging role for PtdIns(4,5)P2-mediated signalling in human disease

Trends Pharmacol Sci. 2005 Dec;26(12):654-60. doi: 10.1016/ Epub 2005 Oct 25.


Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2) appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bipolar Disorder / metabolism*
  • Heart Diseases / metabolism*
  • Humans
  • Ion Channels / metabolism*
  • Oculocerebrorenal Syndrome / metabolism*
  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositol Phosphates / metabolism*
  • Signal Transduction*


  • Ion Channels
  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositol Phosphates