Extrauterine life duration and ontogenic EEG parameters in preterm newborns with and without major ultrasound brain lesions

Abstract

Objective: To determine whether extrauterine life duration is associated with different ontogenic electroencephalographic (EEG) patterns in premature infants compared with neonates born at later gestational ages (GAs).

Methods: We included 97 preterm infants of 24-36 weeks GA. We performed neurosonography and EEG recordings at week 1 and 2 of postnatal life, then every two weeks until term conceptional age (CA). We analyzed background EEG and sleep states and compared them at matched CA.

Results: In the group of infants without major ultrasound lesion (MUL), those <29 weeks GA showed increased sawtooth at 32-36 weeks CA and delta brushes from 34 to 40 weeks CA compared to infants > or =29 weeks GA. Infants with MUL compared to those without MUL showed significantly longer interburst intervals, shorter minimum burst duration at 2 and 4 weeks postnatal life, and higher incidence of sawtooth and delta brushes from 34 weeks CA to term. In addition, those of <29 weeks GA had higher rates of indeterminate sleep until 32 weeks CA. The type of MUL most frequently associated with dysmature EEG patterns was persistent ventricular dilatation.

Conclusions: Premature infants without MUL showed prolonged dysmature EEG patterns as from early CAs (> or =29 weeks). This finding was more evident in those with MUL.

Significance: Extrauterine EEG development in prematures may differ from that of babies born at a later GA.