Abstract
The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated kinases (Paks), previously best known for their role in cytoskeletal and transcriptional signaling pathways, also play an important role in centrosome dynamics via phosphorylation and activation of Aurora-A.
MeSH terms
-
Aurora Kinases
-
Cell Cycle Proteins / metabolism*
-
Centrosome / metabolism
-
Cytoskeleton / metabolism
-
Guanine Nucleotide Exchange Factors / metabolism
-
Humans
-
Models, Biological
-
Protein Serine-Threonine Kinases / genetics
-
Protein Serine-Threonine Kinases / metabolism*
-
Rho Guanine Nucleotide Exchange Factors
-
Signal Transduction / physiology
-
p21-Activated Kinases
Substances
-
Cell Cycle Proteins
-
Guanine Nucleotide Exchange Factors
-
Rho Guanine Nucleotide Exchange Factors
-
Aurora Kinases
-
Protein Serine-Threonine Kinases
-
p21-Activated Kinases