Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease

Neurobiol Aging. 2006 Nov;27(11):1537-53. doi: 10.1016/j.neurobiolaging.2005.09.020. Epub 2005 Oct 27.


In the last decade, it has become more apparent the important role genes play in the development of late-onset Alzheimer's disease (AD). Great efforts, involving human genome scans and candidate gene studies, have been given towards identifying susceptibility genes for AD. A number of regions on different chromosomes have been reported to demonstrate linkage for AD. Of these, findings on chromosome 12 are some of the most compelling. Worldwide genetic association studies pre-dating and subsequent to recent linkage studies have identified and focused upon a number of genes that map to the areas of reported linkage on chromosome 12, however, analyses of those genes studied to date, on the whole, remain inconclusive and ambiguous. This paper reviews studies that have provided evidence of linkage for AD on chromosome 12 and in turn discusses the work conducted to date on candidate genes that have been identified and map to the chromosome 12 regions of interest.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • DNA-Binding Proteins / genetics
  • Genetic Predisposition to Disease*
  • Humans
  • Linkage Disequilibrium
  • Low Density Lipoprotein Receptor-Related Protein-1 / genetics
  • Receptors, LDL / genetics
  • Telomere / genetics
  • Transcription Factors / genetics


  • DNA-Binding Proteins
  • Low Density Lipoprotein Receptor-Related Protein-1
  • Receptors, LDL
  • TFCP2 protein, human
  • Transcription Factors