Mitochondrial respiratory chain and free radical generation in stroke

Free Radic Biol Med. 2005 Nov 15;39(10):1291-304. doi: 10.1016/j.freeradbiomed.2005.07.010. Epub 2005 Aug 19.


Being the second most common cause of death in the industrial countries and one of the major causes of death and disability, stroke has a great effect on public health and is the neurological disease which accounts for the largest number of hospitalizations. In order to develop new treatments, biochemical mechanisms involved in brain damage have been investigated. Among them, oxidant species generated during stroke have been implicated as critical mediators of neuronal injury in this condition, although neuroprotective roles have also been demonstrated. This review is focused on the role of the mitochondrial respiratory chain as both source and target of reactive oxygen and nitrogen species such as nitric oxide, superoxide and peroxynitrite produced in cerebral ischemia. The neuroprotective role of antioxidants or other molecules acting on the mitochondrial respiratory chain and ATP synthesis in the setting of cerebral ischemia is discussed.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Adenosine Triphosphate / metabolism
  • Animals
  • Antioxidants / metabolism
  • Brain / pathology
  • Brain Ischemia / pathology
  • Electron Transport Chain Complex Proteins / physiology*
  • Electron Transport Complex I / physiology*
  • Free Radicals*
  • Humans
  • Mitochondria / pathology
  • Models, Biological
  • Neuroprotective Agents / pharmacology
  • Nitric Oxide / chemistry
  • Nitric Oxide / metabolism
  • Oxidants / chemistry
  • Oxygen / chemistry
  • Peroxynitrous Acid / metabolism
  • Phosphorylation
  • Stroke / pathology*
  • Superoxides / chemistry
  • Time Factors


  • Antioxidants
  • Electron Transport Chain Complex Proteins
  • Free Radicals
  • Neuroprotective Agents
  • Oxidants
  • Superoxides
  • Peroxynitrous Acid
  • Nitric Oxide
  • Adenosine Triphosphate
  • Electron Transport Complex I
  • Oxygen