Ribosomal proteins in the spotlight

Crit Rev Biochem Mol Biol. Sep-Oct 2005;40(5):243-67. doi: 10.1080/10409230500256523.


The assignment of specific ribosomal functions to individual ribosomal proteins is difficult due to the enormous cooperativity of the ribosome; however, important roles for distinct ribosomal proteins are becoming evident. Although rRNA has a major role in certain aspects of ribosomal function, such as decoding and peptidyl-transferase activity, ribosomal proteins are nevertheless essential for the assembly and optimal functioning of the ribosome. This is particularly true in the context of interactions at the entrance pore for mRNA, for the translation-factor binding site and at the tunnel exit, where both chaperones and complexes associated with protein transport through membranes bind.

Publication types

  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Humans
  • Models, Molecular
  • Molecular Chaperones / metabolism
  • RNA, Ribosomal / metabolism*
  • Ribosomal Proteins / analysis
  • Ribosomal Proteins / biosynthesis
  • Ribosomal Proteins / physiology*
  • Ribosomes / chemistry*
  • Ribosomes / metabolism


  • Molecular Chaperones
  • RNA, Ribosomal
  • Ribosomal Proteins